Quantitative determination of Domperidone and Paracetamol in combined dosage form by FT-IR spectroscopy
نویسندگان
چکیده
A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Paracetamol (PAR) through FT-IR in combined dosage form. The method involves the measurements of peaks of carbonyl group (C=O) at 1656 cm (PAR) and 1717 cm (DMP). An UV-Spectrophotometric method was also described for the simultaneous determination of DMP and PAR. The analytical results obtained with FT-IR showed very good correlation with UV-Spectrophotometric method. The method was validated for pharmaceuticals in tablet form and found to be highly precise with high recovery levels (>99%).
منابع مشابه
Quantitative determination of Domperidone and Ranitidine in combined dosage form by FT-IR spectroscopy
A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Ranitidine (RAN) through FT-IR in combined dosage form. The method involves the measurement of peaks of amine (-NH) at 1620 cm -1 (RAN) and carbonyl group (C=O) at 1717 cm -1 (DMP). The method was validated for pharmaceuticals in tablet form and found to be precise with high recovery levels (>99%).
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